CAUSES OF NEPHROTIC SYNDROME

CAUSES OF NEPHROTIC SYNDROME

• It is glomerular basement membrane disease characterised by

  • Massive proteinuria

  • Hypoalbuminemia

  • Hyperlipidemia and lipiduria

  • Generalized edema

Causes of nephrotic syndrome are 

Primary causes 

• Membranous nephropathy

• Minimal change disease

• Focal segmental glomerulonephritis

• Membranoproliferative glomerulonephritis

• Other proliferative glomerulonephritis (Ig A nephropathy)

Secondary causes

• Diabetes Mellitus

• Amyloidosis

• SLE

• Drugs (NSAID, Pencillamine, heroine)

• Infections (malaria, syphilis, hepatitis B and C, HIV)

• Malignant disease (carcinoma, lymphoma)

• Miscellaneous (Bee-sting allergy, hereditary nephritis)

Reference 

1. Vinay kumar, Abul K.Abbas, Nelson Fausto, Jon C. Aster. Robbins and Cotran Pathologic basis of disease. 8th edition.
2. Harsh mohan. Text book of Pathology.8th edition.2019
3. A.K.Mandal, Dr. Sharmana Choudhary. Textbook of Pathology for MBBS. Vol II. Second edition 2017.