CNS manifestations in AIDS

CNS MANIFESTATIONS IN AIDS
  • Neuropathologic changes in AIDS is because of viral products and by soluble factors produced by infected microglia (IL-1, TNF and IL-6)
  • Soluble gp120 directly cause damage to neurons
  • Patient develops
    • Dementia
    • Meningoencephalitis
    • Aseptic meningitis
    • Vacuolar myelopathy
    • Peripheral neuropathy
    • Demyelinating lesions of spinal cord
    • Progressive multifocal leukoencephalopathy
    • Non-Hodgkins lymphoma of brain 
Reference
Kumar Abbas, Abul K. Abbas, Jon C Aster. Robbins and Cotran Pathologic Basis of Disease. 9 edition.