GIANT CELL LESIONS OF BONE

GIANT CELL LESIONS OF BONE

• Non -neoplastic conditions

  • Metabolic bone disorders/ Genetic 

    • Hyperparathyroidism – Brown tumor

    • Pagets disease of bone

    • Cherubism –

      • Autosomal inherited disorder with mutations in SH3BP2gene characterized by bilateral, painless, symmetric fibro-osseous lesions confined to maxilla and mandible

    • Noonan-like/ multiple giant cell lesion syndrome – associated with  germ-line mutations of PTPN11 gene characterized by bilateral central giant cell lesions in the mandible and has phenotypic overlap with Noonan syndrome

  • Infections 

    • Tuberculosis

    • Syphilis

    • Fungal lesions

  • Cystic lesions 

    • Aneurysmal bone cyst

    • Traumatic bone cyst

  • Tumor like lesion

    • Giant cell reparative granuloma

• Neoplastic lesions

  • Benign

    • Non – ossifying fibroma

    • Chondroblastoma

    • Chondromyxoid fibroma

    • Langerhans cell histiocytosis

    • Pigmented villonodular synovitis

  • Malignant 

    • Giant cell rich Osteosarcoma

    • Telangiectatic Osteosarcoma

    • Clear cell chondrosarcoma

    • Malignant fibrous histiocytoma

    • Metastatic carcinoma

• Tumor of unknown origin

  • Giant cell tumor