morphology of Pleomorphic adenoma

Morphology of Pleomorphic adenoma
Gross :
  • Well encapsulated, round to ovoid mass with smooth nodular surface 
  • Cut surface is gray white with translucent zones representing cartilaginous and myxochondroid areas
Microscopic findings
  • Capsulated lesion composed of epithelial and mesenchymal like tissues
  • Epithelial component consists of well formed ducts, sheets, cords, anastomosing trabeculae and cystic spaces. Epithelial cell types are cuboidal, basaloid, plasmacytoid, spindle shaped, oncocytic or squamous.
  • Mesenchymal  like component is constituted by myxoid, hyaline, chondroid and osseous areas.
  • PAS positive material is seen in the lumen of the cystic spaces