Neoplasms in AIDS

NEOPLASMS IN AIDS

• Patients have high incidence of tumors which are caused by oncogenic DNA virus

Tumors which occur in HIV patients are

• Kaposi sarcoma –Human  herpes virus 8

• Non-hodgkins lymphoma – Epstein Bar Virus

• Cervical cancer in women – Human papilloma virus

• Anal cancer in men – Human papilloma virus

Kaposi sarcoma

• Human Herpes virus 8 is responsible for Kaposi sarcoma

• Characterized by the proliferation of spindle shaped cells that express markers of both endothelial cells and smooth muscle cells

• Lytic replication in the cell leads to release of growth factors like VEGF which leads to replication

• Kaposi sarcoma occurring in HIV patients is different from sporadic form that it produces widespread lesions

Lymphomas

3 groups of lymphomas occur in HIV patients

• Systemic Non-Hodgkins lymphoma

• CNS primary lymphoma

• Body cavity based lymphoma

Reference