Anaplastic oligodendroglioma
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Grade III tumors (Anaplastic oligodendroglioma)
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Cellular tumors
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Nuclear hyperchromasia is present
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Brisk mitotic activity (>6 mitotic figures/10 HPF)
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Microvascular proliferation (intraluminal endothelial cell proliferation)
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Necrosis may be present but perinecrotic pseudopalisading is usually absent
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Eosinophilic “astrocyte like cytoplasm, either with prominent processes that resemble astrocytoma (Gliofibrillary oligodendrocytes) or spindle cell change is seen in grade III neoplasm
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Well circumscribed epithelioid like appearance
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Minigemistocytes are common in grade III
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm. Atypical mitotic figures are seen. (H&E,X400)
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm. Atypical mitotic figures are seen. (H&E,X400)
Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X400)
Anaplastic oligodendroglioma: Areas of necrosis (right) with adjacent foci showing pleomorphic cells having hyperchromatic nuclei (H&E,X100)
Anaplastic oligodendroglioma: Areas of necrosis with pleomorphic tumor cells having hyperchromatic nuclei (H&E,X100)
Anaplastic oligodendroglioma: Foci of the tumor showing oligodendrocytes with perinuclear halo (H&E,X400)
Anaplastic oligodendroglioma: Sheets of minigemistocytes and lymphocytic infiltrate (H&E,X100)
Anaplastic oligodendrglioma: Sheets of minigemisticytes (H&E,X400)
Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X100)
Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X400)
Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X400)
Anaplastic oligodendroglioma: Tumor showing hypercellularity with delicate vascular channels (H&E,X100)
Anaplastic oligodendroglioma: tumor cells showing nuclear pleomorphism and atypical mitotic figures (H&E,X400)
Anaplastic oligodendroglioma: tumor cells showing nuclear pleomorphism and atypical mitotic figures. Delicate vascular channels are noted. (H&E,X400)