1. A 65 year old male was admitted with breathing difficulty. History of sudden onset of high fever, chills and cough with mucopurulent sputum. X-ray chest shows radioopaque lesion in the left lung lower lobe. Laboratory findings as follows: positive gram stain on sputum noted
a. What is the provisional diagnosis
b. Write the gross pathology and stages in this condition
c. Describe the difference between the two morphologic types
d. Labelled microscopic diagram of the disease
2. A 65 year old man, a chronic smoker, presented with history of weight loss, low grade fever and difficulty in breathing. He gave history of hemoptysis for last month. X-ray chest showed enlarged right tracheobronchial lymph nodes. Bronchoscopy revealed a fungating growth in the right bronchus.
d. What is paraneoplastic syndrome? Give features of paraneoplastic syndrome
(Answer: Bronchogenic carcinoma) (NTRUHS Feb 2018)
3. A 55 years old lady present with breathlessness and cough for the past 2 weeks. She gives history of loss of weight and tiredness for the past 6 months. X-ray chest revealed a massive pleural effusion on the left side. CT scan showed a nodular mass which is peripherally located in the left lung. CT guided biopsy of the mass showed large cells with pleomorphic nuclei and prominent nucleoli arranged in glandular pattern.
a. What is your diagnosis
b. Mention the histological types (Subclassification) of this lesion with illustrations
c. Describe its etiopathogenesis
(Answer: Adenocarcinoma of lung) (NTRUHS Jan 2015)
4. A male aged 60 years who is a chronic smoker presented with history of slowly increasing severe exertional dyspnoea and weight loss. He is barrel-chested and dyspneic with prolonged expiration, sits forward in a hunched-over position and breaths through pursed lips
5. An elderly male, chronic smoker presented with steadily progressive dyspnoea. On examination he was found to be barrel chested and dyspnoeic with prolonged Expiration, sits forward in a hunched over position and breaths through pursed Lips. Chest X-ray revealed hyperinflation and small heart
6. 60years old man habituated to tobacco smoking came with history of cough, haemoptysis, dyspnoea, loss of weight, severe pain in the distribution of the ulnar nerve and Horner’s syndrome. Mention various laboratory investigations to make a final diagnosis. Describe the pathology of the lesion
(Answer: lung carcinoma) (NTRUHS Sep 2003)
A 40 year old female presented with history of chronic cough with profuse expectoration, occasional haemoptysis and also clubbing with coarse crepitation in right lung base.
a. What is your probable diagnosis?
b. Discuss the etiopathogenesis& pathology of the target organ involved.
(Answer : Bronchiectasis) (RGUHS, Jun 2010)
7.Discuss about the etiopathogenesis, classification, pathology and morphology of Bronchogenic carcinoma (NTRUHS Oct .2002, RGUHS-Jul 2008)
9. Classify lung tumors. Discuss the pathogenesis, morphology and clinical features including paraneoplastic syndromes of Squamous cell carcinoma of lung (RGUHS, Dec 2013)