Inadequate formation of granulation tissue leads to two types of complications
Wound dehiscence
Ulceration
Excessive formation of the components of repair process leads to formation of
Hypertrophic scars – accumulation of excess amounts of collagen gives rise to raised scar called hypertrophic scar
Keloids – scar tissue grows beyond the boundaries of the original wound and oes not regress
Exuberant granulation tissue – formation of excessive amounts of granulation tissue which protrudes above the level of surrounding skin and blocks re-epithelialization. It is removed by surgical excision
Desmoids or aggressive fibromatoses – incisional scars or traumatic injuries followed by excessive proliferation of fibroblasts
Contracture – exaggerated contraction of wound results in deformities of wound and surrounding structures.
They develop mostly in palms, soles and anterior aspect of thorax
Also seen in burns and may compromise the movement of joint
Development of Carcinoma in scars – eg squamous cell carcinoma may develop in Marjolin’s ulcer which is formed after burns in skin
References
Vinay kumar, Abul K.Abbas, Nelson Fausto, Jon C. Aster. Robbins and Cotran Pathologic basis of disease. 9th edition.
Harsh mohan. Text book of Pathology.8th edition.2019