It is type of non-bacterial endocarditis associated with Systemic Lupus Erythematosus
Valves commonly involved – Mitral and tricuspid valves with sterile vegetations
Morphology
Gross
Vegetations are small measuring 1 to 4mm in diameter
Occuring as multiple, sterile, pink vegetations with a warty appearance
Location – Both on the atrial and ventriculr surface atrioventricular valves, Valvular endocardium, chords and mural endocardium of atria or ventricles
Microscopy
Vegetations consists of finely granular fibrinous eosinophilic material containing cellular debris including nuclear remnants, neutrophils, lymphocytes and histiocytes
Vegetations are associated with an intense valvulitis, characterized by fibrinoid necrosis of valve substance and reflecting the activation of complement and recruitment of Fc receptor bearing cells
Reference
Vinay kumar, Abul K.Abbas, Nelson Fausto, Jon C. Aster. Robbins and Cotran Pathologic basis of disease. 8th edition
